As I’ve stated before... I feel like Tobey will be bringing in a seasoned, but knowledgeable type Peter Parker. Have some hope, but will have some loss ala May (use Tomei to pull at heart strings), or if it’s MJ instead who’s passed, just use it to have him teach Tom to be strong.
While... Andrew on the other hand will be even made jaded and be a bit more reckless with the duty as Spider-Man, post Gwen’s death. Maybe coming too closely from crossing the edge. And, this crossover will either end in sacrifice or he’ll be a better man from it. Learning from Tobey and maybe from Tom.
I strongly feel that both Spider-Men will come
in with some additional loss (if in fact their character doesn’t die in this film) after their film canon. It’ll be no different that what we’ve seen -“already using a Peter who lost an MJ/Gwen/May in the Ultimate Comics or Spider-Verse to bring in some emotion to the crazy sci-fi scenario.