As far as Marvel adaptations go the small, subtle scene when Peter (in Spider Man 2) guiltily tells Aunt May the truth about what he was doing the day Uncle Ben got killed at her dinner table gets me every time due to her reaction (she stands up and walks off whilst the camera just lingers on Peter momentarily).
For all their 'cheesiness' the Spider-Man movies(well the first two), at their best, have worked beautifully because of the unpredictable character based moments which, imo, even with X2 and IRON MAN, are still the best I've yet seen in a Marvel movie.
If we're talking comic based movies from any company there have been many(from Donner's SUPERMAN to THE DARK KNIGHT) but one that gets me is the moment we see Selina Kyle (in her kitchen, post murder attempt) turn into Catwoman in BATMAN RETURNS. What the scene displays, when she's playing back her answering machine messages as she drinks milk, is how this woman has been driven to madness by being bullied and let down by EVERYBODY in her life(from her mother to boyfriends who dump her to her murderous boss).
Pfeiffer(how come this woman still hasn't an Oscar) brilliantly puts across the dark, psychological tint Burton intended for his vision of Batman better than any actor assigned to play one of his eccentrics.
