I highly doubt that Sony is gonna somehow drop the major cliffhanger elements from the last film. I doubt it will even be a soft reboot. Given the way the last one ended , the next story if anything , lends itself to a more isolated Peter Parker who is gonna have to stand on his own without the help of Fury or the Avengers.
Sony needs to focus on what's always matter, deal be damned, and that's Peter Parker . Not Tony Stark, not Thanos, but Peter Parker and his struggles.
The MCU interconnected stuff , for me , was gravy , and was nice . But it's more important to have a good Peter Parker story than it is to make reference to other characters movies or have guest appearances by other heroes.
My concern about this whole thing is not that Spiderman can't hang with Thor anymore. Its that the quality of the solo films will go down and we'll end up with another ASM 2 or SM3.
Imo, anyone calling themselves a Spiderman fan should hope and root for the next film to be as good if not better than the last as opposed to rooting for failure under Sony.