I would love to see Los Espookys animated for a Hanna Barbera style Mystery Inc. xover.
Los Espookys (likely by design) being the counterparts to the Mystery Inc. premise, where Mystery Inc. investigate and solve the Mystery, Los Espookys are instead the the ones hired to create and instigate the mystery.
Of course by end, they would work together to bring down the real villain.
I Imagine their Mystery Inc. counterparts would be:
Fred - Renaldo - the Defacto leader, supernatural aficionado who assembles the team, optimistic go-getter, drives the Van
Daphne - Andrés - the rich spoiled, pretty one, can be self serving, may have a legit supernatural connection.
Velma - Úrsula - the brains, smart, resourceful, down to earth and pragmatic one.
Shaggy & Scooby- Tati - The somewhat dimwitted, flakey dreamer, who can be manipulated to try anything, oddly ends up inadvertently helping.