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Well some AV software wont run in safe mode, so it can depend on what kind you have. Whatever the case there you can find out by going the av control center from the 'start menu>programs' in safe mode. If it can run then do a full scan on your primary (OS) hard drive (and scan within archives* if you can), and if it can't run then you should go for the 'system restore'.
*I mention this as it looks like the file creating the problem at start up is not the virus itself, but something that creates/unpacks the trojan every time you reboot: this is why it keeps coming back after deletion when you start up again.
Also look at your start up items and delete anything that looks suspicious (you can download a trial version of "Tune Up Utilities" that has a decent and easy to use start menu editor)
I ran my AV in safe mode and it removed 2 Trojans, I then went back to normal and my cursor was still the same, so i tried to restore but it wont let me, it just keeps saying "cannot restore" to the point i try for, I can't find a way to restore via safe mode, so what do i try now ?
Thanks for all the help btw.