Look Spidey has always been Marvel's flagship. As Stan Lee most famously said, "It's kind of like Walt Disney and Mickey Mouse, when people think Walt Disney, they think of Mickey Mouse. When people think Stan Lee, for those who don't think 'who's that' they think of Spider-man."
I think TASM2 has the potential to be the definitive Spider-man film, so potentially the kind of boost that we saw from Batman Begins to TDK. But much of that will depend on the reviews.
Having said that, I think CATWS is going to surprise people. Now I say that with some reluctance as that's what I thought about Thor TDW. However in retrospect, there seems to have been some production problems with that film along the way. They had all the right pieces, something just didn't click.
I have been very impressed by what I've seen from CATWS so far, but we'll see if it holds.