Spider-Man the Character
1. Death of Uncle Ben
2. Night of the Goblins
3. Death of Peter's Parents (no one mentioned this?)
4. Death of Gwen Stacy
5. Death of Peter
6. May being shot, along with the unmasking
7. Return of Peter's Parents only to turn out to be evil robots, oh by the way he's also been a clone
8. Harry turning evil/good/evil and death of Harry
9. May's death
10. Buried alive by Kraven
Spider-Man the Comic
1. Clones
2. JMS
3. the Q
4. tie-ins that shouldn't be, especially with mutants
5. Gwen the ****
6. the 90's
7. Symbiote babies (except carnage)
8. Tony Stark
9. Peter, Peter, wife beater
10. Ben Reilly (I know clones was the first point, but I really hate that backstreet boy.)