Just came back from this, and as someone who actually played the arcade game when I was a kid, I was mildly disappointed that the animals didn't revert to human form at any point. That might've been added an interesting angle.
Pretty entertaining movie overall, and although most of the human characters were cliche, they were the fun sort of cliche so it wasn't that bad. And the way Malin Akerman and her brother got offed was pretty damn entertaining, I mean wow, what a way to go for Malin Akerman (which had my audience rolling), and the brother's was a good chuckle too, especially with Jeffrey Dean Morgan's line afterwards.
My only complaint, which is sort of a nitpick, was that the animals weren't large enough. George was sort of puny compared to Ralph, who in turn was noticeably smaller than Lizzie. Also, while the destruction porn was awesome, I was a bit disappointed that we didn't see more of all 3 of them side-swiping into buildings and intentionally causing them to crumble, to sort of echo the gameplay mechanics that the game had. And I don't get why both Ralph and Lizzie were [blackout]killed off either, it could've been better if they were kept alive for a potential sequel[/blackout]. But it was a decent flick and I wouldn't mind a sequel if they do end up making one.