I'd rather she not be a genderbent character. Is there really a good female villain already around she can't play?
All the theory lists just do the same people over and over. Silvermane. The Beast of the Hand, Head of IGH, and Mephisto. Not saying Mephisto can't absolutely not have a female Earth form that maybe Weaver is just one female form. But IMHO going right to Mephisto for Defenders just seems like an odd choice.
I think the Beast is a good choice because it would build on plot threads from Daredevil and gives the group an epic threat they have never faced before, someone like Sunset Bain would seem like old hat at this point and really the Beast doesn't have a gender, so Weaver could play it.
Some of the choices on this thread, like Ruby Thursday, Mandrill or Foggy's mom, are really out of left field choices that just don't work, there is no build up with those guys, most of them would not work as the Big Bad of this series, they would not fit, they would not be threaten enough or you have to change them so much their comic book counterparts you change them into different characters.
I like the Beast, someone like Sunset Bain would be an okay choice, but you have to work hard to make her something other then yet corporate scum bag, who we have seen before in the MCU and choices like Ruby Thursday, Rosalie Sharpe and Mandrill, are just really bad, IMO.
Well Madame Masque could've worked if they hadn't already used Whitney Frost in Agent Carter. If they make her Whitney Frost now who is Madame Masque, then that's explictly saying that the character in Agent Carter doesn't count and that it's actually not all connected.
I don't know why they had to use Whitney Frost in Agent Carter anyway, since she was nothing like the actual comic character and had different powers. They could've just made her an original character.
Although Madame Masque (the comic character) wouldn't be able to take on DD, Jessica Jones, Luke Cage and Iron Fist. Maybe in regular hand-to-hand combat, but when it comes to someone like Luke Cage she'd be outclassed and wouldn't even be able to put a dent in him.
But Masque is a crime boss, couldn't she just pay people to fight the Defenders? Weaver is in her 60s, she is not going to be a credible physical threat to a group of characters who are all half her age, not taking into account the Defenders powers and abilities.
Either she can be a corporate tycoon like Sunset Bain and have her fight the Defenders with technology, influence and mercs or you make her into the Beast and she is a super natural threat, who fights with psychic powers and the ability to posses people.
Either Sunset Bain or the Beast could build on threads we saw in the other shows, that wouldn't be out of left field choice like Mandrill.