Lantern Venom, I don't think I've met anyone who over appreciates such rubbish comic book characters like Venom, and under appreciates the brilliant ones like Ock. It's like you're a template guide as to how not view the Spidey villains.
Everything you said Lizard and Goblin could oppose Spidey with Ock could and did too, and many times even more impressively. He was not fighting Spider-Man with his flesh and blood body so I don't know why him being chubby or needing glasses makes any difference (Just like Molina's Doc Ock with his belly and man boobs sticking out were not used to pummel Spidey, rip off vault doors, flip over cars etc). Ock fought with his tentacles which were plenty formidable. Apart from being easily capable of whupping Spidey with his tentacles, he could total trains with them, topples buildings, or casually fend off the Sinister Six attacking while smoking a cigarette;
I'd love to see Goblin and Lizard perform feats like that so effortlessly (one of the many advantages of mentally controlling mechanical appendages. They will never get tired like flesh and bone do). You'd be more valid to this ridiculous line of criticism on someone like the Vulture. A bald 80 year old man who did actually combat Spider-Man with his frail body.
No offense though it is hardly surprising that a Venom fan, a character who rose to popularity because of shallow reasons like his look and powers, would have such weak invalid criticisms like this against Ock. I can only credit your post for at least recognizing the brilliance of Molina's Ock, and concurring that the tentacle design in Spider-Man 2 is the best one he's ever had.
Ock's unimpressive physical appearance was to show he was still the nerdy looking, chubby, bullied, repressed bitter person which shaped him into becoming the super villain he was. He faced all the same slights Peter Parker did before he got his powers; bullied in school, unpopular with girls, no friends, ostracized for being a specky four eyes science nerd, lost a parent, grew up in middle class New York etc. But unlike Peter when he got his powers he didn't lose the specs, or get in good physical shape, and become a force of good. Ock took the new found power he got and used it to lash out at the world. He didn't use his great power with great responsibility. Again that can also be traced back to his upbringing. Where Peter had loving parents like Uncle Ben and Aunt May who supported and encouraged him and instilled good moral values like with great power comes great responsibility into him, Ock had a horrible verbally abusive father and a clinging, emotionally blackmailing over bearing mother. His father used to verbally shout at him that he was a wimp and that a man his measured by is strength and power when Otto would come home beaten up by the school bullies. His mother would always tell him he's a genius who was better than the others. The type of ego centric traits we all know and love Ock for. So Ock never had the love and good upbringing Peter had with Ben and May. All these reasons are why they call Doc Ock the Peter Parker gone bad. He's the mirror image of Peter had he turned villain.
An idea that Raimi so brilliantly incorporated thematically into Spider-Man 2 by having Ock and Peter's arcs reflect each other. Peter was being irresponsible by giving up being Spider-Man so he could live his dream of a normal happy life. Ock was being irresponsible by doing evil things to make his dream of building his life's work succeed. That's why Peter was able to relay the same words of wisdom to Ock about your dreams that Aunt May had to Peter earlier in the movie. It applied to both of them.