After the end of the Season 4, I wondered if Melinda May was the one character who could legitimately "go bad" that other characters didn't. From her time in the Framework, she now understands that killing Katya Belyakov was the right thing to do. But that might not be a good thing.
From her time in the Framework, could May decide that the time has come to kill all Inhumans? (A few in-jokes about the Inhumans having a rigid, unfair caste system could work.) And the fact that Daisy would die as well does not fit into the equation.
"How can you do this? Daisy is your friend."
"Skye was my friend. Daisy is the daughter of two mass murderers who saw themselves as better than the rest of us."