Eh, using most of the Rogues as serious villains is tricky at best. The GA is willing to buy a lot, but you really don't want your audience asking "How did the Flash get hit by a boomerang? He just evacuated an entire hospital in the blink of an eye." Hiro got that on Heroes, and he at least had some good excuses at first.
That's a problem the Flash has in general: he has a great rogues gallery, but most of them would be horrid to adapt to the screen. Grodd is a talking gorilla, Mirror Master is a walking escapee from the silver age, most of the Rogues require Flash's cooperation to actually challenge the guy...
Best choices for a main villain are the Trickster, Abrakadabra, or one of the speedsters.
The Trickster, really? He's the weakest of the Rogues.
All the Rogues could be done in a movie, but they'd have to be rewriten. Their powers, enhanced. Their costumes, redesigned, and their motivations, rewriten, to allow them to actually want to kill the Flash instead of just stealing valuables and staying out of his way.
Captain Cold, by example. He has been reinvented by Francis Manapul as a metahuman that can freeze the molecules around his body, creating a "cold field" that slows down anything that comes too close. He can bring the Flash down to human level, or even make him moronic, in addition to stopping anything the Flash tries to throw at him from a distance. In addition to the other common portrayals of ice and cold manipulation.
Mirror Master. He's a teleporter. He can use any reflexive surface as a gateway in and out. Can you imagine that. He could have access to you from several places in your room. Not to mention he's armed with lasers that can burn through glass, and weapons that can blind you, make you lose control of your nervous system, and much more.
Weather Wizard. He controls all the weather that surrounds you at will. He can manipulate circunstances to such an extent that everything can kill you. He can open tornados inside your body, lower your body temperature until you die, or simply throw a lightning at you.
They're all VERY dangerous.