Also, I'd love to see the Framework spin-off get reactivated where we get to see new actors play familiar characters in a world ruled by HYDRA (and John Hannah). A world where Thor never got his hammer back and is currently a construction worker named Sigurd Jarlson, Tony Stark has no armor and is just a businessman until HYDRA shuts his company down, Hulk is simply a researcher for Stark, War Machine is an Air Force colonel plotting a coup against HYDRA, Steve Rogers is still floating around somewhere in the Arctic, Hawkeye is a wanted fugitive and Black Widow is a HYDRA agent hunting them all down since they may one day be threats. Future seasons would have them band together and the final season would involve them becoming The Avengers. Season 2 would have Quicksilver, Scarlet Witch, Falcon, Wasp, Doctor Strange, Captain Marvel, Vision, Black Panther and Ant-Man show up. Season 3 would bring in the Defenders.
I'd handle the later characters like this. Quicksilver and Scarlet Witch are simply brother and sister but are discovering that there may be some hidden potential in them. Falcon would be a psychologist who would take on Thor as a patient. Ant-Man and Wasp are Hank and Janet and they're younger in this world and just starting to learn how to shrink things. Doctor Strange is simply a surgeon. Captain Marvel is a fighter pilot who joins in with Jim Rhodes' rebellion. Vision is just a computer program. Black Panther is still a prince who's in America to try to get HYDRA to leave Wakanda alone and respect his father's independence. Daredevil is just a blind lawyer who is discovering that his senses may actually be superhuman and winds up representing Hawkeye in court. Jessica Jones was never experimented on and is a private investigator who can expose HYDRA. Luke Cage is Hawkeye's cellmate. Iron Fist was never lost in K'un-L'un and is instead the heir to his company but his father's business partner may be attempting to plot against him in the name of HYDRA. Punisher and Winter Soldier are HYDRA's best assassins but Frank is beginning to doubt his cause and Bucky reminds Frank that he's a family man...
If Marvel can get permission, then Spider-Man should also show up as a small child who would be a small cameo.
Then what remains of Ultron gets into the code and in a world where the heroes of the MCU don't have their powers yet (and the few who do don't know how to use them), things go from bad to worse.
Penultimate season involves characters gaining/mastering their powers. Final season is the only one with costumes.